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Dana-Farber/Harvard Cancer Center

Breast Cancer Symposium


Co-Chairs: J. Dirk Iglehart, MD and Paula Ryan, MD, PhD


April 7, 2006


The Harvard Club

Boston, Massachusetts


LIST OF ABSTRACTS

CELL BIOLOGY AND SIGNALING





1

Dhara Amin, Diane Bielenberg, Michael Klagsbrun

Breast carcinoma-derived endothelial cells as novel targets of anti-EGFR therapeutics


2

Jérôme Eeckhoute, Jason S. Carroll, Timothy R. Geistlinger, Maria I. Torres-Arzayus and Myles Brown

Combinatorial transcriptional network required for estrogen regulation of cyclin D1 and cell cycle progression in breast cancer cells


3

Kirsten C. Fertuck, Jason Carroll, Marisa Torres-Arzayus, Ray-Chang Wu, Bert O’Malley, and Myles Brown

^ Coactivation by AIB1 contributes to long-range association between proximal and distal estrogen receptor binding sites in breast cancer cells


4

Samuel Godar, Tan A. Ince, and Robert A. Weinberg

p53 inactivation promotes tumorigenesis by increasing CD44 expression


5

Andrew A. Horwitz and Jeffrey D. Parvin

^ BRCA1 regulation of transcription: direct stimulation of preinitiation complexes and also repression via the E3 ubiquitin ligase activity


6

Jingyung Hur, Pablo C Hilario, Kathleen L Dean, Erica M Tobey, Shannon L Smith, Keiko Shioda, Kathryn R Coser, Kurt J Isselbacher, and Toshi Shioda

Regulation of expression of BIK proapoptotic protein in human breast cancer cells: p53-dependent induction of BIK mRNA by fulvestrant and proteasomal degradation of BIK protein


7

Tan A. Ince, Andrea Richardson, Maki Saitoh, James D. Iglehart and Robert A. Weinberg

^ Cell of origin determines phenotype and expression profile of breast tumors


8

Mariela Jaskelioff, Richard Maser, Bin Feng and Ronald A. Depinho

High-resolution genomic profiling of sporadic murine mammary adenocarcinoma


9

Ha-Won Jeong, Zhigang Li, Matthew Brown, David B. Sacks

^ IQGAP1 binds Rap1 and regulates adhesion- and forskolin-mediated Rap1 activation


10

Erika K. Keeton, Jason S. Carroll and Myles Brown

GATA-3 function in estrogen receptor activity and breast cancer cell growth

11

Susan A. Krum and Myles Brown

^ The differential induction of apoptosis by estradiol in the breast and in bone


12

Jessica Mar, Renee Rubio, and John Quackenbush

Inferring single-cell gene expression distributions from analysis of mesoscopic samples


13

Sandra S. McAllister, Matthew P. Saelzler, Tan A. Ince, Stephen P. Kelleher, Ferenc Reinhart and Robert A. Weinberg

^ Systemic support of tumor progression and other bone-headed ideas


14

Meng Qiao, Thomas M. Roberts, James D. Iglehart, and Arthur B. Pardee

Breast cancer progression in the 21T erbB2+ ER  cell lines


15

Roopali Roy, Ulla M. Wewer and Marsha A. Moses

^ Exploring the role of ADAM12 in breast cancer


16

Satish Sankaran, Jeffrey D. Parvin

BRCA1 in association with BARD1 regulates centrosome dependent microtubule nucleation


17

Sarah R Walker, Erik A Nelson, and David A Frank

^ Opposing roles of STAT5 and STAT3 in breast cancer


18

Jiang Yang, Diane Bielenberg and Marsha A. Moses

Overexpression of neutrophil gelatinase-associated lipocalin (NGAL) induces the epithelial-mesenchymal transition (EMT) in breast cancer cells


19

Xiuwei Yang and Martin E. Hemler

Roles of CD151 in induction and progression of breast cancer

^
RISK, PREVENTION AND DISPARITIES




20

Aedín C. Culhane, Renee Rubio, Venkataramu Chinnambally, Timothy Yeatman, John Quackenbush

Extracting predictors of breast cancer risk by integrated analysis of molecular signatures of histologically non-malignant breast tissue


21

Janet S de Moor, Ann H. Partridge, Karen M. Emmons, Eric P. Winer

^ Socioeconomic predictors of adjustment following ductal carcinoma in situ


22

Andrea Gurmankin Levy, Seema Sonnad, Jibby Kurichi, Melani Sherman, Sanghamitra Savadatti, Katrina Armstrong

Making sense of breast cancer risk assessment tools on the web


23

MJ Kandel, Z Stadler, S Masciari, L Collins, S Schnitt, L Harris, A Miron, A Richardson, JE Garber

^ Prevalence of BRCA1 mutations in triple negative breast cancer


24

Alexander Miron, Robert W. Gordon, Rong Wang, Janet Yang, Xin Lu, Frederick P. Li , Dee W. West, Esther M. John, Alice S. Whittemore, James D. Iglehart and Judy E. Garber

^ Shape based sequencing (SBS) a rapid, inexpensive and sensitive procedure


25

Susan E. Pories, Carolyn C. Lamb, Roopali Roy, Margaret M. Lotz, David Zurakowski, Sughra Raza, Ulla Wewer, Rochelle G. Scheib, Susan Schumer, Alexis Exarhopoulos, Nina Isakovich, Gwendolyn Louis, Ankur Anand, Corrine Lenahan, Susan Kilroy, Judi Hirshfield-Bartek, Barbara H. Yee, Marsha A. Moses

^ Multiplexing urinary biomarkers: a novel non-invasive methodology for breast cancer risk assessment


26

Teresa Rufo, Corinne Lenahan, Carolyn Lamb M.D., Margaret Edwards R..T. R.M., and Susan Pories M.D.

The increasing incidence of risk markers





^ ADDITIONAL ABSTRACTS FOR RISK, PREVENTION AND DISPARITIES


A1

David G. Cox, Peter Kraft, Paul Pharoah

A haplotype of the estrogen receptor beta (ERS2) gene is associated with an increase in breast cancer risk


A2

A. Heather Eliassen, Graham A. Colditz, Bernard Rosner, Walter C. Willett, Susan E. Hankinson
Adult weight change in relation to breast cancer risk




A3

Rulla M. Tamimi, Celia Byrne, Graham A. Colditz, Susan E. Hankinson

^ Endogenous hormone levels, mammographic density, and subsequent risk of breast cancer in postmenopausal women


A4

Shelley S. Tworoger, A. Heather Eliassen, Christos Mantzoros, Graham A. Colditz, Walter C. Willett, Susan E. Hankinson

Plasma adiponectin concentrations and risk of incident breast cancer

^
GENETICS AND GENOMICS




27

Martin Aryee, John Quakenbush

Accelerating interactome mapping


28

Andrea Bafford, Hongfeng Chen, Sridhar Ramaswamy, James D. Iglehart, Andrea Richardson, and Zhigang C. Wang

Multiple patterns of genetic evolution exist in primary and metastatic breast cancers


29

Jason S. Carroll., Shirley X. Liu, Wei Li, Cliff A. Meyer, Jun Song and Myles Brown
^

Genome-wide mapping of estrogen receptor binding and activity





30

Scott L. Carter, Aron C. Eklund, Isaac S. Kohane, Lyndsay N. Harris, and Zoltan Szallasi

A putative signature of chromosomal instability inferred from gene-expression profiles predicts poor prognosis in breast cancer


31

Carol Chang, Joseph White, Eleanor Howe, John Quackenbush

iAMP, an internet automated microarray pipeline at DFHCC


32

Amira Djebbari and John Quackenbush

^ Construction of genetic networks from the biological literature and microarray data


33

Timothy R. Geistlinger, Jason S. Carroll, and Myles Brown

Genome-wide mapping of progesterone receptor binding and activity in breast and endometrial cancer cells


34

So Young Kim, Jason Moffat, David Root, William C. Hahn

^ Gaining insight into the genetic basis of breast cancer through the use of a genome scale RNAi library


35

Wei Li, Clifford A. Meyer, W. Evan Johnson, Jun Song, Jason S. Carroll, QianbenWang, Myles Brown and X. Shirley Liu

^ Model-based analysis of tiling-array (Mat) and its application towards the first definition of the nuclear receptor regulome


36

Fenglong Liu, Joseph White, Razvan Sultana, Corina Antonescu, Valentin Antonescu, John Quackenbush

^ A collection of cancer gene expression data at DFCI


37

Kaveh Maghsoudi, John Quackenbush, X. Shirley Liu

Gene expression in tiling arrays using a two-state hidden markov model


38

Clifford A. Meyer, Jun Song and X. Shirley Liu

^ Combinatorial and positional characteristics of estrogen receptor binding sites


39

J Quackenbush, C Antonescu, V Antonescu, M Aryee, C Chang, A Culhane, A Djebbari, E Howe, F Liu, K Maghsoudi, J Mar, P Papastamos, R Rubio, R Sultana, W Wang, J White

^ Cancer computational biology at DFHCC


40

Toshi Shioda, Jessica Chesnes, Kathryn R Coser, Lihua Zhou,Jingyung Hur, Kathleen L Dean,

Pablo C Hilario, Erica M Tobey, Shannon L Smith, Keiko Shioda, and Kurt J Isselbacher

Critical importance of objective criteria for standardizing ligand doses in pharmacogenomics studies to establish and compare transcriptomal signature profiles of hormonally active compounds: approaches employing quantitative phenotype and marker gene expression


41

Zhigang Charles Wang, Yan Li, Xin Lu, Weixiu Luo, Andrea L. Richardson

^ Amplification of the long arm region 22 of chromosome 8 and metastasis of breast cancers


42

Joseph White, John Quackenbush, Corina Antonescu, Valentin Antonescu, Martin Aryee, Carol Chang, Aedin Culhane, Eleanor Howe, Fenglong Liu, Kaveh Maghsoudi, Jessica Mar, Patricia Papastamos, Renee Rubio, Razvan Sultana, Wendy Wang

Databases for human cancer microarray data at DFHCC

^
CLINCAL AND PRE-CLINICAL STUDIES




43

M. E. Abusief, S. A. Missmer, E. S. Ginsburg, J. C. Weeks, E. P., Winer, A. H. Partridge

Relation between gravidity, parity and age at menarche and the likelihood of post-chemotherapy amenorrhea in women with premenopausal breast cancer


44

M. E. Abusief, S. A. Missmer, E. S. Ginsburg, J. C. Weeks, E. P. Winer, A. H. Partridge

^ Chemotherapy-related amenorrhea in women with early breast cancer: the effect of paclitaxel or dose density.

45

MM Chan, X Lu, JD Iglehart, PL Miron

Gene expression profiling of NMU-induced rat mammary tumors: a model of human breast cancer progression


46

Mukesh G Harisinghani, MD, Elizabeth Rafferty, MD, Alphonse Taghian, MD; PhD, Kevin S. Hughes, MD, Mansi Saksena, MD, Ralph Weissleder, MD; PhD

Noninvasive detection of clinically occult lymph node metastases in breast cancer


47

Min Hu, Jun Yao, Li Cai, Kurt E Bachman, Frédéric van den Brûle, Victor Velculescu & Kornelia Polyak
^

Distinct epigenetic changes in the microenvironment of breast tumors





48

Zhe Li, Hanno Hock, Frank Godinho, Laura Yasaitis, Cristina E. Tognon, Chris L. Lannon, Roderick T. Bronson, Poul H. Sorensen, Stuart H. Orkin

^ Identifying the target cell in one form of breast cancer using gene targeted mice


49

Masciari S, Kandel M, DiGianni L, Dillon D, Li F, and Garber J

Histopathologic features of breast cancers in women with germline TP53 mutations


50

Murli Narayan, Danielle M. DesRoches, Jeffrey R. Vachon ,J. Dirk Iglehart, and Lyndsay N. Harris

^ Selection and characterization of HER2 amplified cell lines for resistance to herceptin


51

Parentes JY, Nagano S, Riley M, Jain RK, Boucher Y

Effect of membrane type 1 matrix metalloproteinmase downregulation in the in vitro and in vivo invasion of metastatic human breast carcinoma cells


52

Imran Rizvi, William Rice, Bernhard Ortel and Tayyaba Hasan

^ Epidermal growth factor receptor targeted treatment of breast cancer with photoimmunotherapy


53

Sindhu Singh, Qian Shi, Marek J. Palczewski; Arthur B. Pardee, J. Dirk Iglehart, Debajit K. Biswas

^ Synergistic inhibition by small molecules targeting erbB2 and NFkB signaling in estrogen receptor-negative breast cancer


54

Helen A. Shih, MD, Stephen D. Windsor, BS, Ralph Weissleder, MD, PhD, and Vasilis Ntziachristos, PhD

In-vivo characterization of tumors of Her-2/neu mice using fluorescence molecular tomography


55

Maria I. Torres-Arzayus, Jing Yuan, Jin Zhao, Jamie Dellagatta, Heidi Lane, Andrew Kung and Myles Brown

mTOR inhibition reverses the pre-malignant mammary phenotype in AIB1-Tg mice and inhibits the growth of AIB1-dependent mammary tumors


56

CA Tripp, Y Kondo, and LA Lampson

Visualizable micro-metastases in the rat brain


57

Jean J. Zhao, Hailing Cheng, Zhenning Liu, Shidong Jia and Thomas M. Roberts

The oncogenic role of phosphatidylinositol 3-kinase p110 in breast cancer






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